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Monocyclic Aromatic Amines as Potential Human Carcinogens Old Is New Again

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Alkilanilinlerin Toksik Etkileri

Year 2014, Volume , Effect 1, 31 - 46, 01.01.2014

Abstruse

Mesane kanseri erkeklerde en yaygın görülen üçüncü kanserdir. Pekçok bileşiğe maruziyet mesane kanseri ile ilişkilendirilmektedir ve alkilanilinler bu tip kansere en çok neden olabileceği düşünülen kimyasallardır. İnsanlar alkilanilinlere sigara içme ve kalıcı saç boyaları ile sürekli olarak maruz kalmaktadır. İnsanlarda alkilanilin maruziyeti hemoglobin katım ürünlerinin varlığı ile belirlenmektedir. Hemoglobin katım ürünlerinin oluşumunun kemiricilerde mesane kanseri ve de karaciğer, nazal kavite ve subkütan doku kanserlerine neden olduğundan şüphelenilmektedir. Bunun yanında, alkilanilinlerin in vivo olarak Dna katım ürünlerinin oluşmasına neden oldukları ve Deoxyribonucleic acid katım ürünü oluşumunun metabolik aktivasyonun yan ürünü olarak ortaya çıktığı belirtilmektedir. Bu bileşiklerin ve metabolitlerinin özellikle three,5-aminofenol mutajenik ve genotoksik etkilerinin olduğu gösterilmiştir. 3,5-dimetilanilininin diğer alkilanilinler içinde en yüksek karsinojenik bağlanma indeksine sahiptir ve kemirgenlerde orta derecede karsinojen olarak sınıflandırılmaktadır. Bu derlemede farklı alikilanilinler ve bunların toksik etkilerinden bahsedilecektir.

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Toxic Furnishings of Alkylanilines

Yr 2014, Book , Issue 1, 31 - 46, 01.01.2014

Pınar ERKEKOĞLU

Abstract

Float cancer is the third most common cancer in the globe. Exposure to several compounds is related to bladder cancer occurrence and alkylanilines are the most anticipated chemicals that may cause this type of cancer. Humans are ubiquitously exposed to alkylanilines from cigarette smoking and use of permanent pilus dyes. Exposure has been documented in humans based on hemoglobin adducts. Hemoglobin adduct formation was suspected to pb bladder cancer as well as cancers of liver, nasal cavity and subcutaneous tissue in rodents. Too, alkylanilines were shown to cause Deoxyribonucleic acid adducts in vivo and DNA adduct formation is a byproduct of metabolic activation. These compounds and their metabolites particularly iii,five-dimethylaminophenol were also demonstrated to have mutagenic and genotoxic effects. 3,5-dimethylaniline was shown to have the highest carcinogenic bounden index CBI among other alkylanilines in mice and was classified equally a moderate carcinogen in rodents. This review will focus on unlike alkylanilines and their toxic furnishings.

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Details

Chief Language Turkish
Journal Section Research Article
Authors

Pınar ERKEKOĞLU
Hacettepe Üniversitesi Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı, Ankara

Publication Date Jan 1, 2014
Published in Issue Year 2014, Volume , Effect one

Cite

APA Erkekoğlu, P. (2014). Alkilanilinlerin Toksik Etkileri . Hacettepe University Journal of the Faculty of Pharmacy , (1) , 31-46 . Retrieved from https://dergipark.org.tr/en/pub/hujpharm/outcome/49820/638955

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Source: https://dergipark.org.tr/en/pub/hujpharm/issue/49820/638955

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